v 6. Celiac disease is a disorder of the small intestine characterized by autoimmune response to gluten, a complex of pr

[answerhappygod]

V 6 Celiac Disease Is A Disorder Of The Small Intestine Characterized By Autoimmune Response To Gluten A Complex Of Pr 1 (44.37 KiB) Viewed 98 times

v 6. Celiac disease is a disorder of the small intestine characterized by autoimmune response to gluten, a complex of proteins commonly found in wheat and other grains. Gluten proteins contain Gin-and Pro-rich sequences that are resistant to degradation by digestive proteases such as pepsin, trypsin, and chymotrypsin. Recently, enzyme supplements have been proposed as a potential therapy for patients suffering from this disease. Ono example of these supplements is a cysteine protease that cleaves polypeptide chains on the C-terminal side of Gin residues. Interestingly, the active site contains a catalytic triad of Asp, His, and Cys instead of the expected catalytic dyad. Propose a completo curved-arrow mechanism for the proteolytic cleavage of the gluten peptide segment shown below by the enzyme mentioned above. " มา H R 'N NH, gluten peptide segment