dissolution rates obtained
for the three formulations.
- In Relation To The Noyes Whitney Equation Explain The Dissolution Rates Obtained For The Three Formulations 1 (127.43 KiB) Viewed 57 times
In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations.
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In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations.
In relation to the Noyes-Whitney equation, explain the
dissolution rates obtained
for the three formulations.
5. Danazol is used for the treatment of endometriosis and fibrocystic breast disease. However it is a poorly soluble drug. To improve its solubility, formulations were either prepared using spray -freezing into liquid (SFL) or by slowly freezing the formulation. Data obtained with these formulations are compared against normal bulk danazol. Formulation Surface area (m²/g) 0.52 Contact angle (wettability) Dissolution rate (ranking from fastest (1) to slowest (2) 2 64.3 48 1 Bulk danazol SFL Slowly frozen formulation 83.06 0.35 47.8 2 In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations. (3 marks)
dissolution rates obtained
for the three formulations.
5. Danazol is used for the treatment of endometriosis and fibrocystic breast disease. However it is a poorly soluble drug. To improve its solubility, formulations were either prepared using spray -freezing into liquid (SFL) or by slowly freezing the formulation. Data obtained with these formulations are compared against normal bulk danazol. Formulation Surface area (m²/g) 0.52 Contact angle (wettability) Dissolution rate (ranking from fastest (1) to slowest (2) 2 64.3 48 1 Bulk danazol SFL Slowly frozen formulation 83.06 0.35 47.8 2 In relation to the Noyes-Whitney equation, explain the dissolution rates obtained for the three formulations. (3 marks)