There is an endocrine disorder called central diabetes insipidus, in which the pituitary gland does not make sufficient

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There is an endocrine disorder called central diabetes
insipidus, in which the pituitary gland does not make sufficient
ADH ( Anti-diuretic hormone), leading to abnormally high amounts of
urination. The condition is treated using desmopressin (Minirin), a
synthetic version of human ADH hormone.
Desmopressin is available as a nasal spray taken once daily. It
is not significantly metabolized.
Please answer both question A and B
A) If a patient were to take desmopressin as an IV dose once
daily, would the IV dose be much larger, much smaller, or about the
same amount as the nasal spray dose?
B) A potential side effect of desmopressin is hyponatremia (very
low blood sodium levels). Patients with very low plasma sodium
levels are at high risk of brain seizures. Explain the
pathophysiologic mechanism by which hyponatremia lowers the
threshold for a seizure in the brain.