Neural activation of skeletal muscle involves a sequence of steps. Understanding the steps in this sequence helps you to

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Neural activation of skeletal muscle involves a sequence of
steps. Understanding the steps in this sequence helps you to
determine the locus of disturbances that affect muscle contraction.
You are given an isolated muscle with its motor nerve intact. This
preparation is arranged so that you can make electrophysiological
measurements from the nerve and muscle as well as mechanical
measurements of muscle contraction. You observe that if caffeine is
added to the fluid bathing the muscle preparation, the peak tension
developed in the muscle twitch produced by stimulating the motor
nerve is increased.
1. (2pts) Describe the possible locations at the
neuromuscular junction at which caffeine may exert its effect.
(Think of the steps involved in generating a muscle contraction
starting from the nerve - see mini-lecture on skeletal muscle for
review)