Duchenne Muscular Dystrophy Dmd Is A Disease That Manifests In Muscle Weakness It Exhibits X Linked Recessive Inheri 1 (58.75 KiB) Viewed 151 times
Duchenne Muscular Dystrophy Dmd Is A Disease That Manifests In Muscle Weakness It Exhibits X Linked Recessive Inheri 2 (61.36 KiB) Viewed 151 times
Duchenne Muscular Dystrophy Dmd Is A Disease That Manifests In Muscle Weakness It Exhibits X Linked Recessive Inheri 3 (97.79 KiB) Viewed 151 times
Duchenne Muscular Dystrophy (DMD) is a disease that manifests in muscle weakness. It exhibits X- linked recessive inheritance pattern. The dystrophin gene is large and can have many different mutations along the DNA. From the following mutations between the gene sequence (DNA template strand) of a healthy male and an affected brother determine if they would affect the production of mRNA or the sequence of the protein. Mutation 1 Mutation 2 500 Mutation 4 1235 Mutation 3 1535 + + +5 AGG TTT G 500 1235 1535 + + AGC ATT Base your analysis on the position of the mutation in the transcription unit, and the impact of the change on the codons. D Question 2 2 pts Mutation 1: Position-6 Healthy individual A Affected brother C O Normal mRNA affected protein No mRNA produced (promoter affected) O Abnormal mRNA affected protein O Normal mRNA, normal protein
D D Question 3 Mutation 2: Position +500 (Exon 2) Healthy individual AGA Affected individual AGC O mRNA produced, protein with same amino acid for this codon: SER mRNA produced, protein with different amino acid for this codon (ARG-> SER) O mRNA produced, no protein OmRNA not produced, no protein Question 4 Mutation 3: Position + 1535 (Intron 5) Healthy individual C Affected individual A O mRNA produced, short protein O mRNA produced, no protein produced O mRNA not produced, no protein O mRNA produced, normal protein 2 pts 2 pts
0 Question 5 Mutation 4 Position +1235 (Exon 10) Healthy individual TTT Affected individual ATT O mRNA not produced, no protein OmRNA produced, short protein due to a stop codon O mRNA produced, normal protein produced OmRNA produced, different amino acid in that codon (ILE->MET) Question 6 2 pts Which of the mutations would most likely be the cause of the disease in the affected brother? Mutation 4 O Mutation 2 O Mutation 3 O Mutation 1 2 pts
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