The drug isoniazid used in chemotherapy of tuberculosis is inactivated in the liver, but human variants differ in the ra

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The Drug Isoniazid Used In Chemotherapy Of Tuberculosis Is Inactivated In The Liver But Human Variants Differ In The Ra 1 (46.63 KiB) Viewed 301 times

The drug isoniazid used in chemotherapy of tuberculosis is inactivated in the liver, but human variants differ in the rate of inactivation controlled by allozymes of acetyl transferase. Phenotypes are rapid, slow and intermediate. Dufour et al. (1964) found the following among 209 Japanese tested: 108 rapid, 20 slow and 81 intermediate. 4. Using the Japanese acetyl transferase data, a) Estimate frequency of the rapid allele (R), and the slow allele (r). Hint: use X + Y/2. b) Calculate expected genotype frequencies according to the Hardy-Weinberg model. by What are the g The Hardy-Weinberg population genetics model predicts that if allele frequencies are initially p (for A) and q (for a) in a population, but after generation(s) the genotype frequencies will be for AA, for Aa, and for aa. Allele frequencies at this time will be The model assumes that and and