- Styles 5 Analyze The Electronic Solubility And Steric Effects That Common Functional Groups Can Impart To A Specific 1 (250.22 KiB) Viewed 48 times
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Styles 5. Analyze the electronic, solubility, and steric effects that common functional groups can impart to a specific drug molecule. 6. Identify metabolism of common to common functional groups 7. Explain how a specific functional group can serve different purposes on different drug molecules and how the importance of a specific functional group can vary among different drug molecules based on the influence of the adjacent functional groups 8. Explain the importance of structure-activity relationships principle 9. Explain the nature of a prodrug and provide an example. 10. Discuss how the prodrug concept applies to drug latentiation. 11. Define the pharmacophore 12. Identify the pharmacophores in the structures of the statin drugs and in the structure of clopidogrel. .I I. English (United States) Text Predictions: On Accessibility: Good to go FOCUS BA
13. Define the bioisosteres. 14. Identify bioisosterism in drug congener structures. 15. Define the term congener 16. Draw two congeners within the benzodiazepine molecular class. 17. Explain the difference between covalent and noncovalent bonds. 18. Define alkylation, acylation, pseudo-irreversible acylation, hydroxylation, phosphorylation, carbamylation,, nucleophiles and electrophiles, rearrangement reactions? 19. Provide a definition of a rearrangement reaction.
20. Discuss the strength and distance requirements of ionic bonds. 21. Explain the concept of binding energy (affinity). Understand what a dissociation constant represents. 22. Explain how steric factors and stereochemistry affect the formation of ionic bonds. 23. Explain sequential binding. 24. Know the structures of the amino acids with basic and acidic side chains. 25. Describe polar and nonpolar microenvironments in terms of appropriate amino acids. 26. Explain the reason why amino acids on the biological target and binding drug molecules may ionize even though their pKa values relative to pH 7.4 predict that they shouldn't 27. Discuss factors that can enhance or compromise the solubility of a drug molecule in water. 28. Explain the differences between ion-dipole and dipole-dipole interactions and hydrogen bonding. Focus Text Predictions: On Accessibility: Good to go nglish (United States)
29. Describe the relative strengths and distance requirements for noncovalent bonds. 30. Explain the origin of the van der Waals force. 31. Explain the phenomenon of hydrophobic bonding. 32. Given the chemical structure of a drug molecule, identify the possible interactions than can occur between the drug and its biological target. 33. Describe the behaviors of the noncovalent inter- and intramolecular interactions at various pH values.