1A. The pyruvate dehydrogenase complex is heavily regulated as the nexus between glycolysis and the citric acid cycle: (

[answerhappygod]

1a The Pyruvate Dehydrogenase Complex Is Heavily Regulated As The Nexus Between Glycolysis And The Citric Acid Cycle 1 (101.65 KiB) Viewed 34 times

1A. The pyruvate dehydrogenase complex is heavily regulated as the nexus between glycolysis and the citric acid cycle: (i) NADH (positive regulator || negative regulator) (ii) Fatty Acids (positive regulator || negative regulator) NH₂ 1B. In the pyruvate dehydrogenase complex the cofactor thiamine pyrophosphate (TPP) is used to decarboxylate pyruvate. Provide a drawing that shows the chemical mechanism of decarboxylation. [Show electron pushing and relevant resonance structures. You do not need to show the entire mechanism catalyzed by PDHC. -O OH P-O OH P-OH 1C. What happens next to the pyruvate fragment that is attached to TPP? What cofactor oxidation state of the E2- centered redox cofactor is required to successfully transfer a pyruvate-derived hydroxyethyl fragment from the E₁-bound TPP cofactor onto the E₂ domain? (you can state this in words, no arrow pushing required)