Polyelectrolyte multilayer capsules composed from alginic acid and chitosan have been templated on the surface of porous

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Polyelectrolyte multilayer capsules composed from alginic acid
and chitosan have been templated on the surface of porous calcium
carbonate spherical particles with the average diameters of 5 and
20 µm. Calcium carbonate cores were pre-loaded with the anticancer
drug doxorubicin. Entrapment efficiency for doxorubicin is 85%.
After the CaCO3 core dissolution by the addition of 0.1 M citric
acid, capsules templated on 5 µm particles were unstable and fused
as shown in the scheme below. Capsules templated on 20 µm particles
remain stable after core dissolution. In the first case (5 µm
cores), 30% of pre-loaded doxorubicin has been released from the
capsules and lost during the core dissolution and fusion. In the
case of 20 µm 2 The treatment of carcinoma requires 10 consecutive
injections of 0.5 mg of doxorubicin per kg of a body mass. The
patient has a weight of 80 kg.
Q1. Calculate the amount of doxorubicin needed to prepare (a) 5
and (b) 20 µm alginic acid/chitosan capsules for carcinoma
treatment. (5 Marks)