You need to prepare 80 mL of Ferrous sulfate mixture APF for a
patient.
Ferrous sulfate mixture APF
Ferrous sulfate 3 g
Ascorbic acid 100 mg
Syrup 5 mL
Benzoic acid solution 2 mL
Purified water to 100 mL
Here is some information that may be helpful in answering this
question: (1) Benzoic acid solution contains 5 g of benzoic acid
per 100 mL of solution. (2) Syrup is a 66.7% w/w aqueous solution
of sucrose. (3) The density of the syrup is 1.313 g/mL.
(a) What is the likely function of each ingredient in the above
formulation.
(b) Determine the amounts of the first four ingredients needed
to prepare 80 mL of Ferrous sulfate mixture APF.
(c) What is the ratio strength of ascorbic acid in this
formulation?
(d) In Australia it is a requirement that an oral formulation
must declare on the product label “contains sugars” where “the
presence of sugars may have a significant glycaemic effect and the
total sugar content (including lactose which requires a separate
declaration) exceeds 100 mg per maximum recommended daily dose.”
(from TGO No 91). If the daily dose of Ferrous sulfate mixture APF
is 10 mL, determine the mass of sugar in a 10 mL dose and hence
determine if the statement “contains sugars” needs to be on the
product label.
(e) Determine the concentration of benzoic acid (% w/v) in the
Ferrous sulfate mixture APF.
You need to prepare 80 mL of Ferrous sulfate mixture APF for a patient. Ferrous sulfate mixture APF Ferrous sulfate 3 g
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