Question 6 (8 + 6 + 12 = 26 marks) = A new anti-inflammatory drug in a liquid formulation needs to undergo stability tes

[answerhappygod]

Question 6 8 6 12 26 Marks A New Anti Inflammatory Drug In A Liquid Formulation Needs To Undergo Stability Tes 1 (91.94 KiB) Viewed 65 times

Question 6 (8 + 6 + 12 = 26 marks) = A new anti-inflammatory drug in a liquid formulation needs to undergo stability testing to ensure it has an adequate shelf life. The drug decomposes according to first-order kinetics. Kinetic studies are performed at a number of different temperatures. From the kinetic data, an activation energy of + 156 kJ mol-1 is determined. (a) Determine the degradation rate constant and the half-life for the active in the formulation, if the initial drug concentration is 12.0 mg/mL and the concentration after 34 weeks is 5.42 mg/ml, when stored at 25 °C. (b) The shelf life of the drug formulation is dependent on the concentration of the active remaining at least to 90% of its initial concentration. Determine the shelf life of the drug formulation when it is stored at 25 °C. (c) Using Ea = +156 kJ mol-1, estimate the expected increase in shelf life if the product is stored in the fridge at an average temperature of 6 °C.