Although they have not been successful clinically, why are NMDA receptor antagonists an obvious target to treat ischemic

[answerhappygod]

Although they have not been successful clinically, why are NMDA
receptor antagonists an obvious target to treat ischemic
stroke?
They reduce the glutamate excitotoxicity associated with
ischemic stroke
They have anti-inflammatory properties
They increase the rate and amount of glutamate production
Their primary target is to reduce the occurrence of a further
stroke