- Dopamine 3 4 Dihydroxyphenylethylamine Is An Important Neurotransmitter Associated With Nerve Signalling Since Dopami 1 (256.81 KiB) Viewed 46 times
Dopamine (3,4-dihydroxyphenylethylamine) is an important neurotransmitter associated with nerve signalling. Since dopamine is critical for signal transmissions to the brain, Imbalance levels can lead to many neurological disorders such as schizophrenia, attention deficit, hyperactivity disorder and Parkinson's disease. Hence, Its sensitive and selective detection is important for the early diagnosis of these diseases/disorders for effective treatment. Sensors were developed for the determination of low concentrations of dopamine. The analytical response obtained for each sensor (Ipı, Ip2 and 1p3), when measuring different dopamine concentrations, is listed in table. Note: Table i listed the volume of dopamine added in relation to each concentration analysed where the final volume was 15 ml, and the stock-solution concentration of dopamine was 100 mM. Note 2: All graphs should have correct labels to X-and Y-axis, title to graph and tick lines. Table 1. Analytical response of dopamine obtained for each sensor (pi, lp, and Ipa). Dopamine Sample Ip1 (MA) 1p2 (A) 1p3 (uA) VOLUME (Addition) 0.003 1.22 1.35 1.35 0.006 2.91 2.98 3.22 0.010 5.28 4.33 4.84 0.013 6.91 6.26 7.18 0.016 8.53 8.29 8.90 0.019 10.26 9.95 10.90 0.022 11.85 12.05 13.20 0.026 13.61 14.42 14.83 0.029 15.64 16.22 16.39 0.032 18.45 18.18 18.65 (a) Calculate the concentration range of dopamine analysed in UM. (b) Plot the calibration curve as a standard addition calibration curve, fit a linear model, and define the equation of the line. (c) Add error bars to the plot based on standard deviation (S) values. Comment on the validity of the calibration curves obtained. (d) Justify the feasibility of the calculation and calculate the concentration of dopamine for the analytical response indicated below in table 2 (K, L and M).