Table 1. Gene names, their expression fold changes in Doxorubicin-treated cells and the corresponding P values. Gene nam

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Table 1. Gene names,
their expression fold changes in Doxorubicin-treated cells and the
corresponding P values.
Gene name
Expression fold change
P value
Bax
2.999054
2.37E-05
Pgk1
0.738518
4.97E-09
Zfp365
7.343705
5.55E-199
Fpgt
0.783089
0.584
Svop
6.974837
9.90E-09
Btg2
5.593562
3.06E-210
Rps19
1.205123
0.751
Bbc3
2.34707
1.39E-05
Nudcd2
1.296712
0.621
Klf6
0.609111
5.28E-18
RNA-seq experiments were performed to measure gene expression in
cells treated by an anticancer drug Doxorubicin, as well as in
untreated cells. The table below lists several genes and their
corresponding changes of expression upon treatment as well as
P values. Use this table to answer the following
questions:
1. List the names of
the genes which are down-regulated for the cases where this change
is statistically significant and justify your answer.
2. Briefly explain
how RNA-seq allows determining gene expression fold changes.
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