SHOW YOUR SOLUTION A drug has the following pharmacokinetic parameters: Systemic clearance = 75 L/hr Volume of distribut

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SHOW YOUR SOLUTION
A drug has the following pharmacokinetic parameters:
Systemic clearance = 75 L/hr
Volume of distribution = 1500 L
Fraction excreted unchanged in urine = 0.04
Q1. Calculate an intravenous infusion rate that would maintain a
steady-state blood concentration of 0.2 mg/L.
Q2. Calculate the elimination half-life and time to
steady-state.
Q3. Calculate a loading dose that would give a blood
concentration of 0.2 mg/L. Comment on the implications of the use
of a loading dose for the time taken to reach steady-state.
Q4. Calculate the oral dose rate that would be necessary to
maintain a steady-state blood concentration of 0.2 mg/L. (Assume
absorption from the gastrointestinal tract is complete and liver
blood flow is 90L/hr)