A 67-year old woman presents to the local emergency department with significant discomfort and limited movement in her l

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A 67-year old woman presents to the local emergency department
with significant discomfort and limited movement in her left wrist
following an accident at her son’s residence. Collection of her
medical history reveals that she was a former smoker of 45 years
with a diagnosis of chronic obstructive pulmonary disease (COPD).
At the time, her respiratory physician placed her on triple therapy
(Trelegy Ellipta™; inhaled long acting beta agonist (LABA), long
acting muscarinic antagonist (LAMA), and a corticosteroid). Over
the last year she has experienced frequent exacerbations of her
COPD some requiring hospitalisation, resulting in the regular
prescription of an oral corticosteroid. Based on her history, the
consulting physician orders an X-ray and bone density test,
resulting in a diagnosis of fracture, and also osteoporosis. To
treat the osteoporosis, she is placed on the bisphosphonate,
alendronate (Fosamax™; 10mg, daily).
Drawing from your understanding of pharmacology, what are the
possible consequences of systemic administration of these drug
classes? ​​​​