12) When an internal START is placed within Sec61 in the configuration you drew (orientation 2), it acts as both a START

[answerhappygod]

12 When An Internal Start Is Placed Within Sec61 In The Configuration You Drew Orientation 2 It Acts As Both A Start 1 (88.59 KiB) Viewed 18 times

12) When an internal START is placed within Sec61 in the configuration you drew (orientation 2), it acts as both a START and STOP transfer signal. Which rule explains this? A) START transfer sequences can be placed in either of two hydrophobic grooves within Sec61. B) The ribosome detaches from Sec61 when it can't push the protein through the translocator. C) Internal START signals orient so that positive charged are on the cytoplasmic side of Sec61. D) START and STOP transfer signals reside within the gene that encodes transported proteins. 13) Proteins that use the orientation 2 START configuration depicted in your drawing tend to have the START placed very close to the amino terminus. Why might this be? A) Because signal peptidase just cuts off the internal START signal anyway. B) Because chaperones need to pull the entire NH2 terminus through HH2. C) Because in orientation 2 the SRP has to create a loop that fits within translocator. D) Because Sec61 does not gate laterally for proteins inserted in orientation 2.