- 5 4 5 4 Table 1 Contractionofsmoothmusclebythreeagonists Contractileresponse Mm Log Agonist 10 9 8 5 8 7 5 7 1 (102.93 KiB) Viewed 20 times
-5 -4.5 -4 Table 1.Contractionofsmoothmusclebythreeagonists Contractileresponse(mm) Log(agonist) -10 -9 -8.5 -8 -7.5 -7 -6.5 -6 -5.5 (M) agonist-1 0.2 1.84 9.8 14.8 18 19.6 19.4 20 agonist-2 0 0 0.2 1 2.6 4 7.6 8.8 9.6 agonist-3 0 0 0 0 0.2 2 5.2 10 14.8 20 20 20 9.8 10 10 18 19.6 20 a) Experiments were performed on the contraction of smooth muscleusingincreasingconcentrationsofthreeagonistsandtherespo nsesare given in Table 1. The maximum response of the system was 20mm contraction. Calculate the % maximum response of the systemforeachconcentrationofagonistandplotgraphsshowingthede pendence of the response on log [agonist). Compare the threeagonists in terms of their maximal effect and their potency usingpharmacologicalterms.