b) Table 2. Contraction in mm of smooth muscle by an agonist in thepresenceof increasingconcentrationsof anantagonist. A

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B Table 2 Contraction In Mm Of Smooth Muscle By An Agonist In Thepresenceof Increasingconcentrationsof Anantagonist A 1 (153.3 KiB) Viewed 8 times

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b) Table 2. Contraction in mm of smooth muscle by an agonist in thepresenceof increasingconcentrationsof anantagonist. AntagonistBconcentration = = Agonistcon centration =0 = 1x10-10M 1x10°M = 1x10M 1x107M 0 0 0 0 0 0 0 1 0 1 0 0 3 6 1 1 0 0 1x10TM 3x10 "'M 1x10 'M 3x10 'M 1x10M 3x10M 1x10 M 3x10'M 1x10CM 3x10CM 1x10M 3x10M 1x10 M 3x10 M 1x10PM 0 2 4 9 17 24 29 30 30 30 30 30 30 30 30 0 1 2 4 10 18 25 28 29 30 30 30 30 30 30 1 1 2 14 22 27 29 29 30 30 30 30 2 7 15 22 27 29 7 15 22 27 28 29 29 30 30 i) Plotaconcentration- responsecurvethatshowstherelationshipbetweenagonistconcentratio nand%maximumeffectatEACHoftheconcentrations of antagonist B shown in Table 2 (plot all the data onone graph). ii) Calculatethe EC50 withoutantagonistandwithEACHoftheconcentration sofantagonistused. CalculatetheDoseRatioforEACHoftheantagonistc oncentrations. Writedownyouranswersandshowyourworkings. iii) OnaseparatepieceofgraphpaperconstructaSchildPlot.Fromthisplot,c alculatethepKgvalue oftheantagonist.DefinepKg.