Let's explore some of the physiological implications of these concepts. Hemoglobin is a specific example of how pH affec

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Let S Explore Some Of The Physiological Implications Of These Concepts Hemoglobin Is A Specific Example Of How Ph Affec 1 (71.49 KiB) Viewed 17 times

Let S Explore Some Of The Physiological Implications Of These Concepts Hemoglobin Is A Specific Example Of How Ph Affec 2 (37.21 KiB) Viewed 17 times

Let's explore some of the physiological implications of these concepts. Hemoglobin is a specific example of how pH affects protein function. Every second, your life depends on the protein hemoglobin carrying out its essential function of transporting oxygen to cells throughout your body. How much can a change in pH affect protein function? As previously mentioned the structure, and therefore the function, of a protein is dependent on the interactions of amino acid residues with one another and with other molecules or ions. Since changes in pH can affect the charges on these residues, and changes to the charges can ultimately affect how the residues are able to interact, an appropriate pH is critical to the normal function of a protein, In this way, changes in protonation of some residues of hemoglobin can drastically reduce its ability to transport oxygen. Let's examine how pH affects the protonation states of just a few important amino acids within hemoglobin. Some important interactions are mediated by aspartic acid (Asp), lysine (Lys), and histidine (His) residues, to pick just a few. These interactions rely on a normal blood pH, which is 7.40 in arterial blood. Classify cach amino acid according to whether its side chain is predominantly protonated or deprotonated at a pH of 7.40. The pK, values of the Asp, His, and Lys side chains are 3.65, 6,00, and 10.53, respectively. Protonated Deprotonated
Classify cach amino acid according to whether its side chain is predominantly protonated or deprotonated at a pH of 7.40. The pK, values of the Asp, His, and Lys side chains are 3.65, 6.00, and 10.53, respectively. Protonated Deprotonated Answer Bank His Lys Asp