Imagine you are a biosensor technology consultant who has been asked to advise a company that is developing a portable l

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Imagine You Are A Biosensor Technology Consultant Who Has Been Asked To Advise A Company That Is Developing A Portable L 1 (52.31 KiB) Viewed 40 times

Imagine you are a biosensor technology consultant who has been asked to advise a company that is developing a portable label-free optical DNA biosensor for detecting an inherited disease. The biosensor is based on a hybridisation principle and utilises a ssDNA sequence that is 24 bases long. The final device should be low-cost and disposable. a. Recommend which immobilisation method should be used. Give a description of the method, including one advantage and one disadvantage. (3 marks) b. The metallic thin film onto which the ssDNA is immobilised must be deposited and characterised. Recommend a suitable method for: i, depositing the thin film over an area of 10 mm * 20 mm ii. characterising the surface topography of the entire film ii. characterising the elemental composition of the film. (3 marks) c. Recommend a suitable transducer and explain why it is appropriate for this blosensor. (2 marks) d. Explain why a lab-on-a-chip (LOC) device with microfluidics is appropriate for this biosensor. Give four advantages associated with LOC devices. (4 marks) e. The proposed biosensor needs a power supply that delivers a voltage of 1.55 V and has an energy storage capacity of 150 mAh. This must be sustainable for two weeks. The maximum permissible mass of the energy storage system is 10 g. Referring to the Ragone plot (Figure 9.1 in the Part 2 book and/or the interactive version), what type of energy storage system has a suitable energy density for this requirement? (3 marks)