Model Activity J Structure of Proteins Proteins are pohmers of amino acids. Each amino acid contains a carboxylic acid group -COOH), an amino group (NH), and a side chain group (R). The amino and side chain groups are bound to an a carbon, the carbon next to the carboxylic acid group. Except for Glycine, alla carbons are chiral The pH of most body fluids results in the addition of it to the amine (-NH:-) and the loss of H from the carboxylic acid (-COOH). The resulting debly-bonized structure is called a zwitterion. The 20 different amino acids are classified by the nature of their side chain (R): nonpolar, polar, neutral acidic, and busie. a Carbon a CORT HN CH ОН "HN side chain side chain neutral form zwitterion form In a condensation reaction, two amino acids are joined together by a peptide bond and a molecule of H:0 is formed. A peptide bond is the formation of an amide functional group from the carboxylic acid group of one amino acid and the amine group of another amino acid. Resonance (the movement of electrons in a molecule) creates partial double bond character for the peptide bond, resulting in restricted rotation "HN-CH- -NH-CH=C=0 "HN-CH NH"=CH- R peptide bond Ř double bond R character Further condensation reactions add more amino acids until a polypeptide is formed. The polypeptide chain, with its peptide bonds and sequence of amino acids, is the primary structure of the protein. The secondary structure is created by hydrogen bonds between backbone atoms. Side chain interactions create the tertiary structure. 52
Part 2: Formation of a Dipeptide 1. Get together with another student or team of students and carry out a condensation reaction between the two amino acids. In the space below, write an equation for the reaction with structural formulas. 2. Circle and name the functional group created in this reaction. 3. Name the main product of the reaction: 4. What is the byproduct of the condensation reaction? Model check:
Model Activity J Structure of Proteins Proteins are pohmers of amino acids. Each amino acid contains a carboxylic acid g
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Model Activity J Structure of Proteins Proteins are pohmers of amino acids. Each amino acid contains a carboxylic acid g
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