(e) Pyruvic acid is converted to lactic acid via a Lactate dehydrogenase (LDH)-catalyzed reduction as shown below. Prior

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(e) Pyruvic acid is converted to lactic acid via a Lactate dehydrogenase (LDH)-catalyzed reduction as shown below. Prior

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E Pyruvic Acid Is Converted To Lactic Acid Via A Lactate Dehydrogenase Ldh Catalyzed Reduction As Shown Below Prior 1
E Pyruvic Acid Is Converted To Lactic Acid Via A Lactate Dehydrogenase Ldh Catalyzed Reduction As Shown Below Prior 1 (33.81 KiB) Viewed 89 times
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(e) Pyruvic acid is converted to lactic acid via a Lactate dehydrogenase (LDH)-catalyzed reduction as shown below. Prior to reduction, pyruvic acid binds to the binding site of the LDH enzyme via intermolecular interactions shown below. Explain how hydrogen bonding to the keto oxygen facilitates a faster reaction. (5 marks) HO LDH NADH + H2C HC NAD OH OH Pyruvic acid Lactic acid NADH = Nicotinamide adenosine dinucleotide (reducing agent & cofactor) H-Bond ....... HN Ionic bond
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