wild-type RAG2immunocompromised Questions 17, 18 are based on the experiments shown below. 17. The experiments started w

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Wild Type Rag2immunocompromised Questions 17 18 Are Based On The Experiments Shown Below 17 The Experiments Started W 1 (244.6 KiB) Viewed 40 times

wild-type RAG2immunocompromised Questions 17, 18 are based on the experiments shown below. 17. The experiments started with taking wild type and Rag2-/- knockout mice and induce tumors on them using the 3-MC carcinogen. In the left experiment, tumors from the wild type mice were transplanted into another wild type and Rag2-/- mice. Tumors formed in all the recipient mice. treat with MC carcinogen tramplant into w or RAGhosts transplant into wt or RAG2hosts wt strongly immunogenic Which of the following is a CORRECT interpretation for the result? a. The immune system in both the wild type and Rag2 -/- recipient mice were temporary shutdown. b. There is no such thing called anti-tumor immune response. c. The tumors developed in the recipient mice were due to 3-MC carried in the transplanted cells. d. The tumors in the donor mice contain less antigenic tumor cells. LAG hosts RAG hosts 18. In the right experiment, tumors induced by 3-MC in the Rag2-/- mice were transplanted onto both wild type and Rag2-/- mice. While tumors formed in all the Rag2-/- mice (4 out of 4), presumably due to the lack of antibodies, only half (2 out of 4) of the wild type recipient mice developed tumor. Which of the following can best explain why those tumors failed to form in the two wild type recipient mice? a. Those tumors were highly antigenic and got killed by the anti-tumor immune response in the recipient mice. b. The transplanted tumors had no cancer stem cells. c. Those mice had stronger immune function. d. The lymphocytes in those mice have been attacked and killed by the transplanted tumor cells.