You have engineered cells to carry a complete loss-of- function mutation in the gene encoding p53. Use the following dia

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You Have Engineered Cells To Carry A Complete Loss Of Function Mutation In The Gene Encoding P53 Use The Following Dia 1 (208.63 KiB) Viewed 209 times

You have engineered cells to carry a complete loss-of- function mutation in the gene encoding p53. Use the following diagram to determine what phenotype you would expect these cells to exhibit. Division Signal Differentiation Signal CDK binds Receptor Receptor Cyclin CDK cyclin CDK Inhibitors translocates makes -o-le-ee makes Cyclin CDK TFD PEZF Cyclin Gene CDKI Genes E2F ter S genes p53 DNA Damage protein Select one: O a. The mutant cells would be unable to differentiate in response to the differentiation signal. O b. The mutant cells would be unable to divide because the CDKI genes would block cell division. O c. The mutant cells would be unable to block cell cycle progression in the presence of damaged DNA. O d. None of the other answer choices are correct. O e. More than one of the other answer choices are correct.