How can a cell become cancerous, including the "two-hit" hypothesis, the cell types involved, the rate/method of metasta

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answerhappygod
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How can a cell become cancerous, including the "two-hit" hypothesis, the cell types involved, the rate/method of metasta

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How can a cell become cancerous, including the "two-hit" hypothesis, the cell types involved, the rate/method of metastasis, the role of cyclins/cyclin-dependent kinases, and the involvement of p53/pRb/ATM/oncogenes/suppresor genes/checkpoints?
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