1 Given The Diagrams Below Of Metabolic Pathways For Acetaminophen Apap Metabolism 10 Pnts A Draw A Systems Diagr 1 (29.13 KiB) Viewed 51 times
1 Given The Diagrams Below Of Metabolic Pathways For Acetaminophen Apap Metabolism 10 Pnts A Draw A Systems Diagr 2 (32.17 KiB) Viewed 51 times
1. Given the diagrams below of metabolic pathways for acetaminophen (APAP) metabolism, (10 pnts) A. draw a systems diagram (modeled as a bathroom sink) that allows us to see how APAP is non-toxic at low doses, then experiences a steep dose-[toxic response curve in overdose. (draw your sink diagram below the metabolic pathways; clearly label each flow path (arrow) with the labels used (on detox path arrows) in the right-hand diagram below) [ don't forget Systems are sensitive to inputs: show your input as APAP & arrow(s) 1 (show outputs arrows leading to: ending in the words 'detoxication' or 'toxic injury]
O glucuronidation HON "Me ARAP Glucuronidation Sulation 6.0.COM MINH CYPE WHOO , HONCOOH OH sulfation acetaminophen N-hydroxylation by cytochrome P-450 OH OH hotton 4-6 ougou HO N Me Gluconad Acetaminophen glucuronide Inontokid Acetaminophen sulfate nontonio NCOCH, NAPOI OH Glutathione contin dehydration HEN Reaction with reine andere Me Reactive intermediate NHсос glutathione Me conjugation N Mercapture acid Ulver call death S-gutathione OH S-glutathione OH conjugation with proteins, nucleic acids toxicity Penal excretion NAPOI
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