1. Genetic variation in the activity of cytochrome P450 2D6 (CYP2D6) can lead to decreased (poor metabolisers) or increa

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answerhappygod
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1. Genetic variation in the activity of cytochrome P450 2D6 (CYP2D6) can lead to decreased (poor metabolisers) or increa

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1. Genetic variation
in the activity of cytochrome P450 2D6 (CYP2D6) can lead to
decreased (poor metabolisers) or increased (“ultra”
metabolisers) enzyme activity. Give two (2) examples of
psychiatric drugs metabolised by CYP2D6.
Outline the dose
adjustment required in poor and “ultra” metabolisers for a drug
that is metabolised to an inactive metabolite by this CYP2D6.
Include information on the mechanism of the reaction involved.
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