NAME: 4. (20 points) What produces new cancer therapies? Organic chemistry! In 2021, the drug sotorasib was approved for

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Name 4 20 Points What Produces New Cancer Therapies Organic Chemistry In 2021 The Drug Sotorasib Was Approved For 1 (31.6 KiB) Viewed 49 times

NAME: 4. (20 points) What produces new cancer therapies? Organic chemistry! In 2021, the drug sotorasib was approved for the treatment of a type of lung cancer The drug has an unusual mode of action - it forms a covalent bond to a thiolate group on a cancer-causing protein called K-RAS. The thiolate acts as a Michael donor, and sotorasib acts as a Michael acceptor K-RAS a. In the drawing of sotorasib, circle the four atoms that comprise the Michael acceptor within sotorasib, soforasib b. In the space below, draw the complete arrow.pushing mechanism for the reaction of storasib with K-RAS. You may abbreviate any parts of the drug that are not involved in the reaction with R groups. You may use H2O as a base and H.O as an acid for the mechanism as needed