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7. What happened in the reaction from 10 to 20? Mechanism? Scheme 6. Synthesis of y-Butenolide 8 Оме OME Br LDA, 20 Br T
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7. What happened in the reaction from 10 to 20? Mechanism? Scheme 6. Synthesis of y-Butenolide 8 Оме OME Br LDA, 20 Br T
7. What happened in the reaction from 10 to 20? Mechanism? Scheme 6. Synthesis of y-Butenolide 8 Оме OME Br LDA, 20 Br THF, -78 to 0°C OM OH 85% ОMe 10 1st Grubbs cat. (8 mol %) 21, toluene, 80 °C OME Br then ethylene (1 atm) 2nd Grubbs cat. (4 mol %) 80°C in one pot ОMe 8 81% O 21 НО, triphosgene, Etz CHCI, 0 °C tort 11 20