NACHENIGH_8_NHOHO + 1. BrCN 2. H₂O MANOMA+ R CH₂ R R CH₂-S-CH₂ CH₂ CH₂-OH Proteins can be cleaved specifically at the am

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Nachenigh 8 Nhoho 1 Brcn 2 H O Manoma R Ch R R Ch S Ch Ch Ch Oh Proteins Can Be Cleaved Specifically At The Am 1 (28.93 KiB) Viewed 24 times

NACHENIGH_8_NHOHO + 1. BrCN 2. H₂O MANOMA+ R CH₂ R R CH₂-S-CH₂ CH₂ CH₂-OH Proteins can be cleaved specifically at the amide bond on the carboxyl side of methionine residues by reaction with cyanogen bromide (above). Cleavage proceeds by a four-stage mechanism. The second stage is an internal SN2 reaction, with the carbonyl oxygen of the methionine residue displacing the positively charged sulfur leaving group and forming a five-membered ring product. Draw curved arrows for this step in a way that they lead to the most stable resonance form of the product. Arrow-pushing Instructions :0: :0: :0: NHCHC NHCHC NHCHC ÁNH CÁC NHỊCH R CH₂ R H₂CCN: Previous Next CH3 Email Instructor Save and Exit