Three drinks Four drinks Question 9: The attached figure shows how blood alcohol concentration varies with time and the
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Three drinks Four drinks Question 9: The attached figure shows how blood alcohol concentration varies with time and the
Three drinks Four drinks Question 9: The attached figure shows how blood alcohol concentration varies with time and the number of drinks ingested by eight fasting male subjects. In class we developed a simple model that yielded the following expressions to estimate the observed peaks in the data: Maximum Concentration: CMAX = [DVD]DKE/(KE-KD) VB And the time at maximum: 000 0 1 4 6 7 8 Time (hours) tMAX = Ln(kp/kg) KD - KE Where CDO, VD, VB, KD, and ke, are the initial concentration of the drink, the volume of the digestive system where the drug was initially in, the volume of the body, the rate constant of digestion, and the rate constant of elimination of alcohol from the body. 9a. Does the mathematical expression for the maximum concentration capture the characteristics of the observed peaks? Why? 9b. Does the mathematical expression for the maximum time capture the characteristics of the observed peaks? Why? Blood alcohol concentration (mg%) 100 90 80 70 60 50 40 30 20 10 O One drink □ Two drinks 5
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