Answer Happy

XY is a 34-year-old physician and as a member of doctors without
borders, XY is travelling to a region endemic with malaria. As part
of mission preparation, various medical prophylactic agents are to
be prescribed including doxycycline and primaquine. A pre-mission
physical shows XY is healthy with no overt physical disorders and a
genomic screening analysis provided the following information.
What gene(s) is/are relevant to this case?
What would be your treatment/dosing regimen recommendation be
and why?
FOR ACADEMC PURPOSES ONLY - NOT FOR CLINICAL USE Test Details Gene Genotype CYP2C19 *1/1 CYP2D6 *2/2 Alleles Tested Phenotype Normal Metabolizer Normal Metabolizer *2,3,*4, *4B, *5, 6, 7, 8, 9, *17 *2,3,4,*4M, 6, 7, 8, 9, 10,*12, *14A, 14B,* 17, *29:35,*41 *1D, 2, 3,*3B, 3C, *6,7,8,9 *1B, 2, 3, *12, *17,22 CYP3A5 *3/3 Poor Metabolizer CYP3A4 *1/1B VKORC1 - 1639G>A - 1639G > AG/G *1/1 CYP2C9 *2, 3, 4, 5, 6, *11 Normal Metabolizer Low Warfarin Sensitivity Normal Metabolizer Normal Metabolizer Normalfunction Normal CYP2B6 *6,9 SLCO1B1 521T>C,388A>G *1/1 521T> CT/T rs75527207 G/G *1/1 CFTR Numerous DPYD Normal Metabolizer Numerous TPMT Poor Metabolizer +2, *3A, +3B, *304 GOPD Absent Numerous All HLAB* 15 HLA-B*15:02 HLA-B*57:01 *2/43 563 CT, 202 GA negative/negative negative/ negative negative negative negative negative positive/ negative All HLAB 57 HLA-B*58:01 Negative Negatie Negative Negative Positive All HLAB*58 HLA-A131:01 All HLAA*31 HLA-A*32:01 All HLAA*32 Cancer Biopsy. CfDNA & IHC Test Details: Cancer Gene Gene Status Phenotype