GRAPE FRUIT JUICE
Posted: Tue Sep 07, 2021 8:20 am
GRAPE FRUIT JUICE
required 4. A patient receives a single 400 mg IV dose of a drug that is eliminated exclusively by hepatic LYP3A4 known for its potent inhibitory effect on CYP3A4. The following table shows plasma concentrations following a single 400 mg IV dose of this drug with and without GFJ. enzyme. Today the patient received his dose after drinking large quantity of grapefruit juice (GFJ) that is Time (h) 2 Cp (mg/L) Control 7.78 GFJ 9.8 4 6.06 7.78 6 4.72 6.87 8 3.68 6.06 10 2.86 5.35 12 2.23 4.72 a. Plot the concentration-time data on a semi-log graph paper. b. Calculate t1/2, Vd, CLT, and AUC before and after consumption of GFJ. c. Describe the effect of GFJ on the pharmacokinetics of this drug?
- Grape Fruit Juice 1 (1.31 MiB) Viewed 77 times