A particular compound binds to an active site with the interaction as shown: Due to steric hindrance, the bond indicated
Posted: Wed Apr 27, 2022 6:14 am
A particular compound binds to an active site with the
interaction as shown:
Due to steric hindrance, the bond indicated by the red arrow has
high barrier to rotation and the equilibrium or the rotomers as
shown below does not put the nitrogen group into the correct
position for binding. What changes could you make to lock the
orientation of the compound to ensure that the binding sites line
up?
OOC HBD NH3 Ó... IZ Hydrophobic HBA
NH3 NH 1 خنک IZ IZ
interaction as shown:
- A Particular Compound Binds To An Active Site With The Interaction As Shown Due To Steric Hindrance The Bond Indicated 1 (10.63 KiB) Viewed 42 times
high barrier to rotation and the equilibrium or the rotomers as
shown below does not put the nitrogen group into the correct
position for binding. What changes could you make to lock the
orientation of the compound to ensure that the binding sites line
up?
- A Particular Compound Binds To An Active Site With The Interaction As Shown Due To Steric Hindrance The Bond Indicated 2 (10.01 KiB) Viewed 42 times
NH3 NH 1 خنک IZ IZ