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Posted: **Wed Apr 27, 2022 6:11 am**

: 4 If The Formulation Was Prepared Using Two Propellants Hfa 134a And Hfa 227 In A Ratio Of 0 25 Moles Of Hfa 134a To 0 1 (29.28 KiB) Viewed 25 times

: 4 If The Formulation Was Prepared Using Two Propellants Hfa 134a And Hfa 227 In A Ratio Of 0 25 Moles Of Hfa 134a To 0 2 (32.44 KiB) Viewed 25 times

4. If the formulation was prepared using two propellants HFA-134a and HFA-227 (in a ratio of 0.25 moles of HFA-134a to 0.75 moles of HFA-227), calculate the total vapour pressure achieved in the inhaler in kPa at 20°C. You need to show your calculations. [4 marks] Note: you may refer to the vapour pressure of each propellent (at 20 °C/Table 37.1 in chapter 27 (Pulmonary drug delivery) in Aulton's pharmaceutics (2018).
the total pour reaches them of the per preures of each resort orabnary mature et crund P = Pa + Po the presure of each gas is the product of its more fraction in the more milied by the pour preno the pare 0 for "a" 2000 & ambient preure Pa = xa x pa and the vapour pressure of the pure propellent from Aulton's Pharmaceutics: Number Formula Boiling point (°C) Vapour pressure (kPa) at 20 °C Density (gmL1 at 20°C 134a CFE. -26.5 660 (6.6 bar) 1.23 -17.3 CFH 398 (3.98 bar) 1.41 227