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Pyruvate Oxidation and Krebs Cycle At the end of Glycolysis, molecules of ATP and molecules of NADH have been formed. Also, two 3-carbon molecules of remain. These are still located in the of the cell where Glycolysis occured. For aerobic respiration to occur, they must enter the Draw a Mitochondrion and label: - intermembrane compartment (outer compartment) - matrix - inner membrane - outer membrane - cristae Pyruvate Oxidation Pyruvate oxidation are enzyme-catalyzed rxns that take place in the jelly-like of the mitochondrion. They occur for every pyruvate entering; thus for every glucose molecule. The purpose of these reactions is to convert to (a 2-carbon molecule) which enters the Krebs Cycle. 1. is oxidized as it loses 2 electrons and 1H+to This produces NADH (reduced nicotinamide adenine dinucleotide), an electron carrier molecule. 2. There is an addition of a molecule called and the loss of CO2​. Krebs Cycle 1. The 2-carbon molecule, becomes attached to the 4-carbon Krebs cycle "acceptor" molecule, This forms the 6-carbon molecule, Cycle). , for which the cylce is also known as (Citric Acid 2. Citrate is converted into the 6-carbon 3.
4. also gives up H+and electrons to added. Again, a to produce NADH. A coenzyme-A molecule is reactions is is released. The product of these 5. Briefly, a group binds to the succinyl-CoA and is then transferred to to produce GTP (guanosine triphosphate, a type of high-energy molecule similar to . GTP then donates the This leaves a 4-carbon molecule of 6. Succinate transfers 2H+and 2 electrons to (flavin adenine dinucleotide, another type of electron carrier molecule) producing Thus, FAD has been and succinate has been remains. The molecule 7. H2​O is added to to produce 8. reduces to produce molecule of Krebs cycle, "acceptor" molecule can now unite with another to start the cycle again. Summary of Products For each pyruvate molecule: CO2​, ATP, NADH and FADH2​. For each acetyl-CoA molecule: CO2​, ATP, NADH and FADH2​.