May you please answer all the questions below
Posted: Tue Jul 12, 2022 1:29 pm
May you please answer all the questions below
QUESTION 31 Which of these are potential effects of muscarinic antagonists? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. Reduced bronchial contraction b. Reduced cardiac contraction c. Reduced gastric acid production d. Reduced saliva production e. Reduced sweat production Of. Reduced tear production g. Reduced uterine contraction Oh. Reduced vascular contraction 2.5 points Save Answer
QUESTION 32 Drugs are tested both with and without food because (Some of these statements are correct. Tick ALL that are correct. This question has negative marking but the lowest possible mark for it is 0). a. Some foods contain substances that interfere with metabolism b. More patients drop out of trials if they must fast c. Food changes the absorption rate Od. Drugs may react with substances in food e. None of the above QUESTION 33 Which one of the following describes the transition from Phase Ila to Phase Ilb? O a. Proof of effectiveness O b. Proof of concept O c. Pharmacokinetic proof O d. Proof of safety O e. Proof of mechanism 2.5 points 2.5 points Save Answer Save Answer
QUESTION 34 The parasympathetic nervous system receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓the heart through ✓acting at 2.5 points Save Answer
QUESTION 35 In which of the following conditions might it be therapeutically useful to reduce noradrenergic neurotransmission (at tissue target level)? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. Angina pectoris b. Asthma c. Diarrhoea d. Excessive sweating e. Hypertension f. Incontinence Og. Pheochromocytoma Oh. Tachycardia 2.5 points Save Answer
QUESTION 36 Which of the following is true of rational drug design? O a. Uses existing drugs as a starting point O b. Uses the natural mediator as a lead compound O c. Reduces the molecular weight of a natural mediator O d. Eliminates chiral centres O e. All of the above QUESTION 37 Which one of the following describes the difference between the ED50 and LD50? O a. The safety window O b. The therapeutic index O c. The lethal index Od. The optimal dose O e. The dose to avoid 2.5 points Save Answer 2.5 points Save Answer
QUESTION 38 Complete the sentence below by selecting the appropriate words from the list below. The sympathetic nervous system ✓vasoconstriction through receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓acting at 2.5 points Save Answer
QUESTION 39 Which of the following answers best explains why drugs in Phase I trials are tested in healthy volunteers? O a. They are able to tolerate unexpected toxicity O b. Phase I trials aim to determine Pharmacokinetics O c. There is less variability between healthy individuals O d. All of the above Oe. None of the above 2.5 points Save Answer
QUESTION 40 Which of these are potential effects of adrenoceptor agonists? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. Bladder contraction b. Cardiac contraction c. Iris relaxation d. Reduced tear production e. Reduced nasal mucus production f. Uterine relaxation Og. Vasoconstriction Oh. Watery eyes 2.5 points Save Answer
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QUESTION 32 Drugs are tested both with and without food because (Some of these statements are correct. Tick ALL that are correct. This question has negative marking but the lowest possible mark for it is 0). a. Some foods contain substances that interfere with metabolism b. More patients drop out of trials if they must fast c. Food changes the absorption rate Od. Drugs may react with substances in food e. None of the above QUESTION 33 Which one of the following describes the transition from Phase Ila to Phase Ilb? O a. Proof of effectiveness O b. Proof of concept O c. Pharmacokinetic proof O d. Proof of safety O e. Proof of mechanism 2.5 points 2.5 points Save Answer Save Answer
QUESTION 34 The parasympathetic nervous system receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓the heart through ✓acting at 2.5 points Save Answer
QUESTION 35 In which of the following conditions might it be therapeutically useful to reduce noradrenergic neurotransmission (at tissue target level)? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. Angina pectoris b. Asthma c. Diarrhoea d. Excessive sweating e. Hypertension f. Incontinence Og. Pheochromocytoma Oh. Tachycardia 2.5 points Save Answer
QUESTION 36 Which of the following is true of rational drug design? O a. Uses existing drugs as a starting point O b. Uses the natural mediator as a lead compound O c. Reduces the molecular weight of a natural mediator O d. Eliminates chiral centres O e. All of the above QUESTION 37 Which one of the following describes the difference between the ED50 and LD50? O a. The safety window O b. The therapeutic index O c. The lethal index Od. The optimal dose O e. The dose to avoid 2.5 points Save Answer 2.5 points Save Answer
QUESTION 38 Complete the sentence below by selecting the appropriate words from the list below. The sympathetic nervous system ✓vasoconstriction through receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3 ✓acting at 2.5 points Save Answer
QUESTION 39 Which of the following answers best explains why drugs in Phase I trials are tested in healthy volunteers? O a. They are able to tolerate unexpected toxicity O b. Phase I trials aim to determine Pharmacokinetics O c. There is less variability between healthy individuals O d. All of the above Oe. None of the above 2.5 points Save Answer
QUESTION 40 Which of these are potential effects of adrenoceptor agonists? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0. a. Bladder contraction b. Cardiac contraction c. Iris relaxation d. Reduced tear production e. Reduced nasal mucus production f. Uterine relaxation Og. Vasoconstriction Oh. Watery eyes 2.5 points Save Answer