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This question has multiple parts. Work all the parts to get the most points. Rimantadine was among the first antiviral d
Posted: Tue Jul 12, 2022 1:16 pm
by answerhappygod
- This Question Has Multiple Parts Work All The Parts To Get The Most Points Rimantadine Was Among The First Antiviral D 1 (55.38 KiB) Viewed 43 times
This question has multiple parts. Work all the parts to get the most points. Rimantadine was among the first antiviral drugs to be licensed in the United States to use against the influenza A virus and to treat established illnesses. It is synthesized from adamantane by the following sequence: CH₂=CHBr AlBr₂ (2) Adamantane Br Step 2 proceeds via the following mechanism Bri -Br (5) Br 1-bromcadamantane ChemDoodle (3) Br 1. AlBr, acts as a Lewis acid to yield carbocation 1; 2. Bromoethene acts as a nucleophile to give carbocation 2; 3. Carbocation 2 reacts with nucleophile 3 to give the product of reaction 2. Work out this mechanism on a separate sheet of paper and then draw the structure of carbocation 2. AIF Rimantadine NH₂ starting points ✓
The carbon bonded to the bromine carries the positive charge; it can, therefore, be stabilized by resonance with the halogen. 'Br b What type of reaction is occurring in step 4? [hydrohalogenation Which reagent is necessary for step 4? HBr An error has been detected in your answer. Check for typos, miscalculations etc. before submitting your answer. Submit