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The phosphorylation of glucose to glucose 6-phosphate is the initial step in the catabolism of glucose. The direct phosphorylation of glucose by P; is described by the equation Glucose + P→→→ glucose 6-phosphate + H₂O The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP. Part of the energy from ATP hydrolysis is used to phosphorylate glucose. Keq Glucose + P₁ ATP + H₂O Sum: Glucose + ATP Calculate K'eq at 37.0 °C for the overall reaction. || 1.2 X10-7 AG'° = 13.8 kJ/mol Incorrect glucose 6-phosphate + H₂O ADP + Pi glucose 6-phosphate + ADP AG'° = +13.8 kJ/mol AG'° = -30.5 kJ mol

The maximum solubility of glucose is less than 1 M. The normal physiological concentration of glucose 6-phosphate (G6P) is 250 μM. If the concentration of ATP is 3.38 mM and the concentration of ADP is 1.32 mM, what concentration of glucose is needed to achieve a 250 µM intracellular concentration of G6P? [Glucose] -18.4 Incorrect Determine whether the coupling of ATP hydrolysis to the phosphorylation of glucose provides a feasible route, at least in principle, for the phosphorylation of glucose in the cell. M