In anesthetized rats, topical application of insulin (120 ng/ml) to the brain (via craniotomy) caused an increase (appro
Posted: Mon Jul 11, 2022 2:28 pm
In anesthetized rats, topical application of insulin(120 ng/ml) to the brain (via craniotomy) caused an increase(approximately 30%) in cortical blood flow (Katakam et al., Journalof Cerebral Blood Flow &Metabolism (2009) 29, 1955–1967). Assessmentof the reactivity of isolated rat cerebral arteries showed abiphasic dose-response to insulin, with an initial vasoconstrictionat 0.1 ng/mL, followed by vasodilation at 1 to100 ng/mL.
What cells in the vascular wall mediate thevasoconstrictor response to insulin?
What cells in the vascular wall contribute to thevasodilatory response to insulin?
What pathways are likely to be involved in mediating thevasodilation to insulin?
Could the contribution of these vasodilatory pathways beseparated and evaluated experimentally?
What role would insulin receptors play in mediating itsbiphasic response, i.e., vasoconstriction followed byvasodilation?
What cells in the vascular wall mediate thevasoconstrictor response to insulin?
What cells in the vascular wall contribute to thevasodilatory response to insulin?
What pathways are likely to be involved in mediating thevasodilation to insulin?
Could the contribution of these vasodilatory pathways beseparated and evaluated experimentally?
What role would insulin receptors play in mediating itsbiphasic response, i.e., vasoconstriction followed byvasodilation?