What a difference one base pair change can make! With sickle cell anemia, the mutation in the DNA sequence for the B- gl

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What A Difference One Base Pair Change Can Make With Sickle Cell Anemia The Mutation In The Dna Sequence For The B Gl 1 (57.14 KiB) Viewed 39 times

What a difference one base pair change can make! With sickle cell anemia, the mutation in the DNA sequence for the B- globin gene is a single base pair change in the codon GAG (to GTG). This mutation has an effect only under conditions of low oxygen, when it causes the hemoglobin molecules to aggregate (bunch together), resulting in the characteristic sickle cell shape of the red blood cells. 1. Translate the two codon sequences: Go to page 74 in your textbook (page 72 in the 3rd edition) and identify to which group each of these two amino acids belong (that is acidic, basic, uncharged polar or nonpolar). which has a A GAG codon encodes for a chain. A GUG codon encodes for a chain. which has a side side 2. Briefly explain why you think this one base pair change could have such a catastrophic effect. As part of your explanation, describe where you would expect in a folded protein a polar or charged amino acid to be versus a hydrophobic amino acid.