Perfom structure-activity of the structure of alpidem. SAR analysis as in the example below
Posted: Sun Jul 10, 2022 4:15 pm
Perfom structure-activity of the structure of alpidem. SAR analysis
as in the example below
Perform structure activity identification (SAR) of alpidem that has the estructure. H₂C -CH₂ CI
1-NR group is optimal for activity R Effects of ring A on activity: Aromatic ring heteroaromatic ring -EWG required electronegativity the activity A L 6' in in B 3 N 4 2 H-accepting group ↑ the activity 2-C-O group is importanty for activity 1,2-fused trazole or imidazole ring the activity B substitution with a 3-OH group the activity w/ 3-OH group: polar, readly converted to the excreted glucuronide →↓ DOA w/o 3-OH group: nonpolar, undergo hepatic oxidation & active metabolite DOA 5-phenyl group ↑ activity 2 or 2. 6 substituted with EWG activity 4' substitution activity
- Perfom Structure Activity Of The Structure Of Alpidem Sar Analysis As In The Example Below 1 (23.13 KiB) Viewed 41 times
- Perfom Structure Activity Of The Structure Of Alpidem Sar Analysis As In The Example Below 2 (22.73 KiB) Viewed 41 times
1-NR group is optimal for activity R Effects of ring A on activity: Aromatic ring heteroaromatic ring -EWG required electronegativity the activity A L 6' in in B 3 N 4 2 H-accepting group ↑ the activity 2-C-O group is importanty for activity 1,2-fused trazole or imidazole ring the activity B substitution with a 3-OH group the activity w/ 3-OH group: polar, readly converted to the excreted glucuronide →↓ DOA w/o 3-OH group: nonpolar, undergo hepatic oxidation & active metabolite DOA 5-phenyl group ↑ activity 2 or 2. 6 substituted with EWG activity 4' substitution activity