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13. Briefly explain the difference between 'one-compartment mode pharmacokinetics and "two-compartment model pharmacokinetics. 14. DRUG A is administered as a single IV bolus dose (1 mg/kg) to a 65 year old male patient (75Kg). The drug follows one compartment pharmacokinetics and has an elimination rate constant of 0.116 hr". The apparent volume of distribution is 269L. What is the predicted plasma concentration of DRUG A six hours after the dose was administered to this patient? 5. A patient (60 kg) receives an IV bolus dose of DRUG P (1 mg/kg). Two plasma samples are taken from the patient at 2 hr and 12 hr post-dose. The plasma concentration of DRUG P in these samples was 126 ng/ml and 32 ng/ml, respectively. What is the elimination rate constant for DRUG P?