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Question 1 (2 points) Which one of the following explains why enzymes are very effective catalysts? OA) An enzyme converts a normally endergonic reaction into an exergonic reaction. B) An enzyme preferentially binds the transition state of a reaction. OC) An enzyme releases product(s) very rapidly. D) An enzyme binds very tightly to the substrate(s).
A point mutation of hepatitis C viral protease causes resistance to a drug, which is a competitive inhibitor of the protease. It also results in decreased KM but Vmax is unchanged. Which one of the following statements is most likely to be TRUE? A) The mutation alters the substrate binding site of the protease. B) The mutation causes the protease to unfold. C) The mutation removes an essential catalytic group in the protease active site. D) The mutation promotes drug binding.