Page 1 of 1
Complete the following mechanism showing the cleavage of the peptide bond for the following cysteine protease reaction.
Posted: Wed Jul 06, 2022 11:03 am
by answerhappygod
- Complete The Following Mechanism Showing The Cleavage Of The Peptide Bond For The Following Cysteine Protease Reaction 1 (24.46 KiB) Viewed 28 times
Complete the following mechanism showing the cleavage of the peptide bond for the following cysteine protease reaction. You only need a catalytic dyad for cysteine proteases because the pK, of cysteine is low enough (8) and close enough to the pH of 7.4 that it can easily be deprotonated by histidine. (10 pts.) L NH-R HN Fo H₂C Substrate SH His CH₂ NH -Catalytic Dyad