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3. Given the molecule below has log P=1.447 does Lipinski's rule of five predict it would be an orally active drug? C180
Posted: Wed Jul 06, 2022 11:02 am
by answerhappygod
- 3 Given The Molecule Below Has Log P 1 447 Does Lipinski S Rule Of Five Predict It Would Be An Orally Active Drug C180 1 (43.54 KiB) Viewed 18 times
3. Given the molecule below has log P=1.447 does Lipinski's rule of five predict it would be an orally active drug? C1804NH16CI OH 4. How do (i) hydrophobic, (ii) electronic, and (iii) steric effects affect the activity of drug molecules? How can these different physiochemical properties by quantified? 10g C 5. Given that indoline (R1=R2=H) has log P=0.8 what is log P for the analogue with R1-OMe and R2=F R1 R2 CI NH 6. The following QSAR equation is related to the biological activity of a series of molecules: =-0.24T + 1.40 +1.08MR-0.9 n = 13,r² = 0.89, s = 0.21 What do the different terms mean? What does this imply about the properties needed to optimise activity?