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You may choose more than one answer. From the data in the previous question, which receptor binding drug(s) is/are full agonists? Fold Response 20- 15- -10 Fomoterol Salbutamol Forskolin -6 Conc (log[M]) O Isoproterenol Fomoterol → Salbutamol → Isoproterenol → Forskolin
Choose one answer. From the data below, which drug is a the most potent receptor agonist? (Hint: make sure you are choosing a drug which interacts with a cell surface receptor!) -10 O Fomoterol Salbutamol Forskolin Conc (log[M]) O Isoproterenol Fomoterol Salbutamol Isoproterenol → → Forskolin
You may choose more than one answer. From your interpretation of the image below, what might you conclude? Percent of maximum 100 Drug effect- EC 50 0.1 1.0 Dose (log scale) 10 Drug binding 100 1000 Percent of maximum 100 8 0.1 Full agonist Partial agonist 1.0 Dose (log scale) 10 100 100 O From your analysis of the left-hand figure, you might conclude that receptors must be fully occupied by agonist in order to reach maximal responses. The partial agonist in the right-hand figure is more potent than the full agonist. O The partial agonist in the right-hand figure has greater efficacy than the full agonist. O From your analysis of the left-hand figure, you might conclude that maximal responses can be achieved when less than 50% of receptors are occupied by agonist.