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Pimobendan Vetmedin Ⓡ Absorption Following oral administration the absolute bio-availability of the active principle is 60 -63%. Bioavailability is considerably reduced when pimobendan is administered with food or shortly thereafter. Peak levels were observed 1-4 hours post-dose. Distribution The volume of distribution is 2.6 l/kg. The mean plasma protein binding is 90%. Metabolism The compound is oxidatively demethylated to its major active metabolite. This is then conjugated with sulfate or glucuronic acid. Elimination The main active metabolite is eliminated with a plasma elimination half-life of 2.01 hours. Almost the entire dose is eliminated via feces.
Answer the following questions using the monograph above and any additional information you need to research. 1. 2. 3. 4. 5. 6. What is the trade name for this drug? Vetmedin 7. How much of this drug is lost to first pass effect? a. What route(s) of administration undergo first pass effect? PO What would you expect the half-life to be longer, shorter or the same in cats? a. Why? Would the veterinarian decrease the dose of this drug in animals with concurrent renal disease? a. Why or why not? Does this drug have access to all body compartments? a. What value allowed you to answer this question? In addition to the dose, what additional information should be placed on the label of the medication when dispensing? Pimobendan is often administered in combination with a diuretic and ACE inhibitor. Name the ACE inhibitor most likely used. a. What is the MOA for an ACE inhibitor?