Mr. D.F. is a 37 year old Caucasian male who is 5' 7" with a weight of 103 kg, and a BMI of 35.6 kg/m2. 1. Choose an
Posted: Wed Jul 06, 2022 10:22 am
Mr. D.F. is a 37 year old Caucasian male who is 5' 7" with a weight of 103 kg, and a BMI of 35.6 kg/m2.
1. Choose an appropriate type of weight to be used in estimated drug dosage. Explain your decision.
2. What other clinical information should be considered in determining dosage?
3. Discuss 2 properties that play a significant role in drug distribution in obese individuals. Be detailed.
4. If Mr. D.F. was administered methylprednisolone, how effective would Mr. D. F.'s hepatic drug clearance be during phase I of the metabolic reaction. What causes this?
5. Why is drug clearance in the kidneys generally increased in obese patients?
1. Choose an appropriate type of weight to be used in estimated drug dosage. Explain your decision.
2. What other clinical information should be considered in determining dosage?
3. Discuss 2 properties that play a significant role in drug distribution in obese individuals. Be detailed.
4. If Mr. D.F. was administered methylprednisolone, how effective would Mr. D. F.'s hepatic drug clearance be during phase I of the metabolic reaction. What causes this?
5. Why is drug clearance in the kidneys generally increased in obese patients?